The human-machine collaborative safety protection device, based on UWB precise positioning technology, adopts a modular, miniaturized, and lightweight design. It integrates a dynamic time slot protocol mechanism, a multi-source integrated positioning algorithm, and a differentiated control model for different scenarios, forming an electronic fence. This device achieves active safety protection functions for human-machine collaboration in various underground scenarios, enabling timely early warning and locking of potential safety hazards. The system has a maximum coverage distance of 100 meters and a locking response time of less than 1 second. This solution has been appraised as domestically leading and can play a significant role in preventing major accidents, reducing the impact of mine safety hazards on continuous production, and effectively improving safety production efficiency.